Mammalian sperm undergo discharge of a single, anterior secretory granule following their attachment to the zona pellucida surrounding the oocyte. This secretory discharge is known for historical reasons as the acrosome reaction. It fulfils a number of purposes and without it, sperm are unable to penetrate the zona pellucida and fuse with the oocyte. In this review, we focus on the role of the acrosome reaction in the development of fusion competence in sperm. Any naturally occurring membrane fusion has two (...) major sequential steps: a docking or adhesion step, in which two membranes adhere, and a fusion step, in which their lipid bilayers are destabilized and merged and a cellular compartment is either created or destroyed. Recent evidence suggests that there is an important role for oocyte integrins and sperm‐bound disintegrins in mammalian sperm/oocyte adhesion and fusion. The fusion mechanism employed by sperm remains poorly understood, however, and circumstantial evidence suggests it is more complex than the interaction between a single protein species and its target. Sperm/oocyte fusion is probably the most accessible eukaryotic model for intercellular fusion currently available, partly because it is temporally separated from gene expression. Elucidation of the mechanism of sperm/oocyte fusion may throw light on the mechanism of other intercellular fusions such as myoblast fusion, and the evolutionary relationship of intercellular membrane fusion to intracellular membrane fusion. (shrink)

We show that the actuality operator A is redundant in any propositional modal logic characterized by a class of Kripke models (respectively, neighborhood models). Specifically, we prove that for every formula ${\phi}$ in the propositional modal language with A, there is a formula ${\psi}$ not containing A such that ${\phi}$ and ${\psi}$ are materially equivalent at the actual world in every Kripke model (respectively, neighborhood model). Inspection of the proofs leads to corresponding proof-theoretic results concerning the eliminability of the actuality (...) operator in the actuality extension of any normal propositional modal logic and of any “classical” modal logic. As an application, we provide an alternative proof of a result of Williamson’s to the effect that the compound operator A□ behaves, in any normal logic between T and S5, like the simple necessity operator □ in S5. (shrink)

Gentzen’s and Jaśkowski’s formulations of natural deduction are logically equivalent in the normal sense of those words. However, Gentzen’s formulation more straightforwardly lends itself both to a normalization theorem and to a theory of “meaning” for connectives . The present paper investigates cases where Jaskowski’s formulation seems better suited. These cases range from the phenomenology and epistemology of proof construction to the ways to incorporate novel logical connectives into the language. We close with a demonstration of this latter aspect by (...) considering a Sheffer function for intuitionistic logic. (shrink)

The logic of paradox, LP, is a first-order, three-valued logic that has been advocated by Graham Priest as an appropriate way to represent the possibility of acceptable contradictory statements. Second-order LP is that logic augmented with quantification over predicates. As with classical second-order logic, there are different ways to give the semantic interpretation of sentences of the logic. The different ways give rise to different logical advantages and disadvantages, and we canvass several of these, concluding that it will be extremely (...) difficult to appeal to second-order LP for the purposes that its proponents advocate, until some deep, intricate, and hitherto unarticulated metaphysical advances are made. (shrink)

The manifest appearance of function and purpose in living systems is responsible for the prevalence of apparently teleological explanations of organismic structure and behavior in biology. Although the attribution of function and purpose to living systems is an ancient practice, teleological notions are largely considered ineliminable from modern biological sciences, such as evolutionary biology, genetics, medicine, ethology, and psychiatry, because they play an important explanatory role. Historical and recent examples of teleological claims include the following: The chief function of the (...) heart is the transmission and pumping of the blood through the arteries to the extremities of the body. (Harvey 1616 [1928: 49]) The Predator Detection hypothesis remains the strongest candidate for the function of stotting [by gazelles]. (Caro 1986: 663) The geographic range of human malaria is much wider than the range of the sickle-cell gene. As it happens, other antimalarial genes take over the protective function of the sickle-cell gene in … other warm parts. (Diamond 1994: 83) Despite the substantial amount of data we now have on theropod dinosaurs, more information is necessary in order to determine the likelihood that early feathers served an adaptive function in visual display as opposed to other proposed adaptive functions such as thermoregulation. (Dimond et al. 2011: 62) The ubiquity of claims such as these raises the question: how should apparently teleological notions in biology be understood? Most post-Darwinian approaches attempt to naturalize teleology in biology, in opposition to nineteenth-century viewpoints which grounded it theologically. Nevertheless, biologists and philosophers have continued to question the legitimacy of teleological notions in biology. For instance, Ernst Mayr (1988), identified four reasons why teleological notions remain controversial in biology, namely that they are: vitalistic (positing some special ‘life-force’); requiring backwards causation (because goal-directed explanations seem to use future outcomes to explain present traits); incompatible with mechanistic explanation (because of 1 and 2); mentalistic (attributing the action of mind where there is none). A fifth complaint is that they are not empirically testable (Allen & Bekoff 1995). The current philosophical literature offers both Darwinian and non-Darwinian accounts of teleology in biology that aim to avoid these concerns. In this article, we hope to bring some clarity to the contemporary debates over the role of teleological notions in biology by sketching a taxonomy of the various accounts of biological function on offer (see Allen & Bekoff 1995 for a more comprehensive taxonomy that forms the basis of this presentation). We primarily focus on naturalistic accounts of biological function, since this is where we see the most lively and productive current debates (see, e.g., Garson 2016 for an extended survey). We also briefly discuss the notion of goal-directedness in section 2. (shrink)

Logics that have many truth values—more than just True and False—have been argued to be useful in the analysis of very many philosophical and linguistic puzzles. In this paper, which is a followup to, we will start with a particularly well-motivated four-valued logic that has been studied mainly in its propositional and first-order versions. And we will then investigate its second-order version. This four-valued logic has two natural three-valued extensions: what is called a “gap logic”, and what is called a (...) “glut logic”. We mention various results about the second-order version of these logics as well. And we then follow our earlier papers, where we had added a specific conditional connective to the three valued logics, and now add that connective to the four-valued logic under consideration. We then show that, although this addition is “conservative” in the sense that no new theorems are generated in the four-valued logic unless they employ this new conditional in their statement, nevertheless the resulting second-order versions of these logics with and without the conditional are quite different in important ways. We close with a moral for logical investigations in this realm. (shrink)

A questionnaire on the attitudes towards the functions of research ethical committees was sent to members of selected research ethical committees in Wessex and some controls. Almost all respondents felt there was a need for ethical review of research projects; 42 per cent thought there was a need for some training before joining a committee; 67 per cent thought the system could be improved and 47 per cent thought that monitoring or follow-up procedures should be adopted. Ethical committees were thought (...) to be purely advisory, as opposed to mandatory, by 33 per cent, and 63 per cent thought they should restrict their review to ethical problems as opposed to scientific or design problems. Views about the function of non-medical members ranged from 'none at all' to 'very important'. Of the 10 controls who were asked whether they would become a member of an ethical committee if asked, seven said that on balance they would and the reasons stated varied from the view that it was a 'very important committee' to the feeling that it was 'a necessary but irksome job'. (shrink)

Hegel may be read as endorsing a republican conception of freedom as non-domination. This may then be allied to an expressive conception of freedom not as communal integration and non-alienation, but rather as the development of new powers and capabilities. To this extent, he may be understood as occupying a position between nondomination and expressive freedom. This not only informs contemporary discussions of republicanism and democracy, but also suggests a ‘capabilities solution’ to the otherwise intractable problem of the rabble. Key (...) Words: creativity • democracy • domination • expression • freedom • G.W.F.Hegel • rabble • republicanism. (shrink)

This article deals with a highly debated text, namely 2 Maccabees 12, specifically the problematic verses (38–45) which contain a theology that is distinctly non-Jewish in import. Indeed, most recent scholars concerned with this passage do not seem to be unanimous apropos the best interpretation of the events that are described, resulting in a range of different opinions concerning, inter alia, the afterlife, purgatory and/or doctrinal disputes between Pharisees and Sadducees. By means of an interpretivist or constructivist epistemology, the authors (...) advocate that normally, traditional Judaism emphasises personal, individual responsibility and accountability, whereas in this text God is portrayed as requiring material, financial payment for wrongdoing and not individual תשובה [teshuvah]. This is in contradistinction to, inter alia, Exodus 30:11–16 and theologically Jewish ‘transgression’ has clearly metamorphosed into Christian ‘sin’. In addition, Judas Maccabeus seems to have retained a half-shekel methodology (employed for Jewish men of military age – soldiers) whilst emphasising the ‘atonement for your lives’ from Exodus 30:11–16 in a more literalistic, materialistic, non-Jewish sense whilst de-emphasising the real need to maintain the Temple as well as the proper, traditional rules of תשובה. (shrink)

A difference of opinion exists among some philosophers who have recently inquired whether Marx thinks that capitalism is distributively unjust. What has to be determined is whether in Marx's view the wage worker suffers an injustice in not receiving most or all of the surplus value he creates. Allen Wood argues that this is not Marx's view, and George Brenkert agrees, for quite similar reasons; but Ziyad Husami and Gary Young, on the other hand, argue in reply to Wood, (...) and on overlapping grounds, for the opposite interpretation; Wood, in turn, has defended himself against Husami. (shrink)

Il platonista sostiene che le verità della matematica e della logica siano letteralmente vere, ossia che descrivano (in qualche modo: non voglio legare la definizione a una particolare teoria semantica) realtà che non sono create o decise da noi. Il convenzionalista sostiene invece che le proposizioni che chiamiamo verità della matematica siano in qualche misura convenzionali: esse esprimerebbero convenzioni che abbiamo adottato noi, o certe loro conseguenze. Le due posizioni sono apparenteme...

Given the strong mimetic and dramatic qualities found in Judith the authors make the suggestion that perhaps, before LXX Judith became a fixed, written text, the basic fabula might well have been part of an oral tradition. The authors accept that an appropriately written dramatic work, whether transmitted through reading or an oral presentation, by means of its performative qualities, has the potential to achieve immediacy. Here, the audience may become captivated with its own familiarity and memory of popular, communally (...) shared narratives. Accordingly, this article attempts to find evidence in the Greek text of LXX Judith for a possible oral precursor. In this context, corroboration is sought for the employment of verbal aspect and mood of the Greek language as well as instances of drama, theatrics, bodily gestures, mnemonic devices or special emphasis on the employment of the senses such as sight, taste and smell. The authors suggest that based on an analysis of the text of Chapter 13, there is much circumstantial evidence for the Judith fabula once being an oral narrative – one that embodies the dramatic and even encourages audience participation. This characteristic strongly suggests the removal of the fourth wall – the notion of an imaginary boundary between any fictional work and its audience. Contribution: This article shows that Judith 13 is indeed the climax of the narrative. However, it goes further. It is a vivid scene with various performative aspects. There are props, dialogue and audience participation. This research is cutting-edge and paves the way for new explorations. (shrink)

A difference of opinion exists among some philosophers who have recently inquired whether Marx thinks that capitalism is distributively unjust. What has to be determined is whether in Marx's view the wage worker suffers an injustice in not receiving most or all of the surplus value he creates. Allen Wood argues that this is not Marx's view, and George Brenkert agrees, for quite similar reasons; but Ziyad Husami and Gary Young, on the other hand, argue in reply to Wood, (...) and on overlapping grounds, for the opposite interpretation; Wood, in turn, has defended himself against Husami. (shrink)

The purpose of this article was to compare Jerome’s and Augustine’s sermons on the fifth book of the Psalms with regard to their views on the rich and the poor. After a brief consideration of the different audiences of Jerome and Augustine, we focused on their attitudes to wealth and poverty, and almsgiving and its relationship to eschatology. In both Jerome’s and Augustine’s commentaries we were confronted with problems regarding the nature of the collections, the composition of the audiences, and (...) a lack of overlap between the two works, but it was possible to discern congruences and differences in their exegesis. In their preaching on poverty and riches, both homilists associated Judas with the devil and wealth. With regard to the identification of Christ and the poor, Jerome offers a somewhat uneasy exegesis in explaining that Christ stands at the right hand of the pauper, although the Lord himself is rich. Augustine mentioned the identification of Christ and the poor a few times in Enarrationes in Psalmos and framed the poverty of Christ within the body of the church, emphasising the common humanity of his congregation. In his sermons, mainly delivered to monks, Jerome advocated total renunciation. Augustine made more allowances for human frailty, advocating partial and gradual dispossession. The Songs of Ascent provided both our authors with the opportunity to consider the place of almsgiving in an eschatological context. Contribution: We investigate the views of two prominent Latin fathers on wealth and poverty in their sermons on Psalms 109–150. The focus on wealth and poverty is evident. Judas is identified with the rich and Christ with the poor, placing Christ and riches against each other in an either/or position. (shrink)

There are some Marxist moral philosophers who think that a distinctive and defensible ethic can be unearthed from Marx's writings. The task of unearthing it must, of course, be kept distinct from the task or elaborating and defending it. Professor Aronovitch undertakes both tasks in his paper, but he does not always succeed in keeping them apart. As a result, I believe, damage is done to the exegetical side of his project.The question of whether there is a Marxian ethic is (...) a problem both of textual interpretation and of moral philosophy. Consider, for instance, the claim that Marx has an ethic whose centrepiece is a principle of selfrealization. It is an exegetical problem to provide evidence that a principle of self-realization is to be found in Marx and to explain how he understands it. (shrink)

As one of the most important ethicists to emerge since the Second World War, Alan Gewirth continues to influence philosophical debates concerning morality. In this ground-breaking book, Gewirth's neo-Kantianism, and the communitarian problems discussed, form a dialogue on the foundation of moral theory. Themes of agent-centered constraints, the formal structure of theories, and the relationship between freedom and duty are examined along with such new perspectives as feminism, the Stoics, and Sartre. Gewirth offers a picture of the philosopher's theory and (...) its applications, providing a richer, more complete critical assessement than any which has occurred to date. (shrink)

The Septuagint Book of Judith and its derivatives have had an enormous influence on the history of Western Europe and the Christian church. Judith has been employed in various situations to incite violence against a perceived opposition. In this regard, this article focuses on the climax of this book (Jdt 13:1–9) as performance text. In this context, many of the insights proffered by Perry in his seminal work Insights from Performance Criticism (2016) have been expanded upon from the perspective of (...) a Greek and/or Hellenistic environment.Contribution: The value of reading LXXJudith as performance is clearly demonstrated. The conclusion is reached that this pericope is indeed highly subversive. Suggestion is also made that, contrary to more conservative wisdom, with reference specifically to LXXJudith 13:1–9, the Judith fabula is not really reconciliatory in nature. Rather, it seems to provoke conflict between competing powers. (shrink)

How can computer professionals shape the future of new computing technologies? Using the recent history of handheld computers as an example, this paper investigates how computer professionals can shape the future by helping to define what new technologies should be. Computer professionals can play a variety of roles in creating, maintaining, and questioning problem framings, or the basic assumptions about what problem a new technology is trying to solve. In addition to political activism and professional ethics, computer professionals need to (...) reflect on the process of defining new technological directions, and how they can help shape technology development into outcomes they believe in. (shrink)

Seven important essays on the study of ancient Egyptian religion. Contents: The cosmology of the pyramid texts (James P Allen); Textual criticism in the coffin texts (David P Silverman); State and religion in the New Kingdom (Jan Assmann); The natural philosophy of Akhenaten (James P Allen); Horus or the crocodiles: a juncture of religion and magic in late Dynastic Egypt (Robert K Ritner); Psychology and society in the ancient Egyptian cult of the dead (Alan B Lloyd); Death and (...) initiation in the funerary reliion of ancient Egypt. (shrink)

There is a large body of empirical work that has investigated the relationship between parents’ child-directed speech and their children’s Theory of Mind development. That such a relationship should exist is well motivated from both Theory Theory and Socio-Cultural perspectives. Despite this general convergence, we argue that theoretical differences between the two perspectives suggests nuanced differences in the expected outcomes of the empirical work. Further, the different ontological commitments of the two approaches have guided the design, coding, and analysis of (...) existing research and imply different future directions. We discuss five areas of extant research that can be extended and diversified most coherently by adopting a SC framework. (shrink)

ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on (...) rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework. (shrink)

An alternative to the negative rights slant in animal rights, focusing on abolition and hands-off approaches, has now surfaced within critical animal studies. Indeed, Relational Animal Rights Theory lays a foundation for positive relations of care, mutuality and dependence between species. In so doing, the theory is sensitive to the multitude of ways in which human and non-human animals interact across shared territories. Perhaps the most fruitful development with RART is offered by Donaldson and Kymlicka, insofar as it extends a (...) positive relation also to wild animals. They present a tripartite framework for moral obligations toward non-human... (shrink)

The goal of this study was to assess the relationships between computational approaches to analyzing constructed responses made during reading and individual differences in the foundational skills of reading in college readers. We also explored if these relationships were consistent across texts and samples collected at different institutions and texts. The study made use of archival data that involved college participants who produced typed constructed responses under thinking aloud instructions reading history and science texts. They also took assessments of vocabulary (...) knowledge and proficiency in comprehension. The protocols were analyzed to assess two different ways to determine their cohesion. One approach involved assessing how readers established connections with themselves. The other approach involved assessing connections between the constructed responses and the texts that were read. Additionally, the comparisons were made by assessing both lexical and semantic comparisons. The result showed that both approaches for analyzing cohesion and making the comparisons were correlated with vocabulary knowledge and comprehension proficiency. The implications of the results for theory and practice are discussed. (shrink)

In this paper, we determine whether illegal hunting should be construed as a crime of dissent. Using the Nordic countries as a case study where protest-driven, illegal hunting of protected wolves is on the rise, we reconsider the crime using principles of civil disobedience. We invoke the conditions of intentionality, nonevasion, dialogic effort, non-violence and appeal to parameters of reasonable disagreement about justice and situate the Nordic illegal hunting phenomenon at a nexus between conscientious objection, assisted disobedience and everyday resistance. (...) This examination leads us to contend that the crime has heretofore received an inadequate response limited to punishment and deterrence. This contention finds support in the worsening predicaments of illegal hunting following harsh sanctions and stigmatization. Although hunters publicize injustices through their crimes, we find that killing wolves as a means to deliberative ends disqualifies hunters’ dissent as legitimate disobedience, creating an obligation of deliberative uptake on the part of society. Nonetheless, in a critical contribution to the field of criminal justice, we argue that it is instead the conditions of deliberative suboptimality experienced by hunters that create this obligation of uptake. Hence, in order to fulfill this obligation, we contend that the burden falls on regulatory agencies to better articulate the justifications for the policies that coerce hunters. We also advocate creating novel institutions to provide hunters with effective opportunities for contesting wildlife conservation directives. (shrink)

As John Henry Newman reflected on 'The Idea of a University' more than a century and a half ago, Bradley C. S. Watson brings together some of the nation's most eminent thinkers on higher education to reflect on the nature and purposes of the American university today. Their mordant reflections paint a picture of the American university in crisis. This book is essential reading for thoughtful citizens, scholars, and educational policymakers.